Regularly updated comics
Abby's Agency
Achewood
Alien Loves Predator
Andie Wear
Bad Blood
Basketcase Comics
Bob the Angry Flower
Bored and Evil* - Chronicles the tale of a young man who sells his soul to live at an apartment with monsters. Twice. He's a loser and is insulted, abused, killed and more on a regular basis by his roommates, a bog monster, a werewolf, a sentient tentacle and a killer in a hockey mask. Oh, and Jesus sometimes appears (Mohammed made a guest appearance, once). Sounds strange (and it is!), but very entertaining.
Butternut Squash
Ces't La Vie
Checkerboard Nightmare
Chugworth Academy - Not sure how to explain this one. There's this school, and it has a bunch of teens who sometimes turn into manga. The stories involve a lot of adult themes, risque artwork, comedic violence, and there's a lot of surreal scenes that don't quite make sense to me, but it's somehow addicting.
College Roomies from Hell
Control Alt Delete (Ctrl Alt Del) - A gamer comic with a great storyline, some laugh -out-loud moments and memorable characters. Has some naughty language, but nothing to bad. Unlike some gaming comics, this one is not a bunch of one-off jokes, although occasionally, there are some. In fact, sometimes, the real world melts away and you are inside a game with "what-if" scenerios. Then there is the surreal chef who spouts out nonsense.
Courting Disaster
Cox & Forkum Editorial Cartoons
Crimson Dark - Beautifully rendered comic/space opera/graphic novel, made completely by software such as Poser and Photoshop and such. The artist is also a writer, and it shows. The story is engaging and the characters are fun to watch. The artist also keeps his audience informed of his progress and trials. The story is only in the third chapter (as of my posting this), and has a long way to go, but shows so much promise already. A little dark, but not dirty or overly violent, so far. Still, it's a little too much for the youngest kiddies.
Deuling Analogs - Fun little gaming comic strip. Most of it is just one gag after another, with little continuity and few regular characters. However, the topics range from retro and classic gaming to the very current games. Always interesting, and just a little bit on the racy side (some days, a little more than that). Great artwork, and I enjoy the artist's news bites where he explains (without making it unfunny) the strip of the day.
Dinosaur Comics
Dog Complex
Down to Earth
El Goonish Shive - Funny name, great comic. The topic is a little bit strange, with furries, transformations and transgendered experiences, not to mention duplicate opposite selves and living goo. Honestly, my description doesn't do justice to the comic. Why? Because it is about characters. One storyline can take months, but you stick with it because you care what happens to these characters. Well worth the read.
The Epilogue
Evil Inc.
Extra Life - Fun little comic about geek life. Features gaming humor, cyberculture, technology, movies and more. No ongoing story, just one or two-shot gags. Pretty funny, with decent artwork.
Foxtrot
Freefall
The Front
Funny Farm
General Protection Fault
Goats
Greystone Inn
Hackneyed Productions
I Am Geek - A newer strip about a couple of friends, male and female, who live together and who are geeks trying to spread the word about what a be a geek. Has blocky, fun artwork.
Idiot Box - Political comics in the vein of Red Meat. Has a liberal slant. Good writing, very topical.
Incubus
Instant Classic
Jason Love's Dailies
Kristy Vs. the Zombie Army
The License
Least I Could Do - Sex comedy done comic style. The main character is highly insensitive and selfish and mysogynist, but somehow, this comic is still appealing reading. Three different artists render this strip (during three different eras). However, the writing is what has impressed me most. It has remained dirty throughout the life of the strip, but the character development seems to have taken off and become more important in the last two or so years.
Lore Brand Comics
Loserz
Make with the Funny
Man-man Comics
Martin's Misdirection
Melonpool
Minions
Newshounds
Nowhere Girl
Ornery Boy
The Outer Circle
Overcompensating
Partially Clips
Penny and Aggie
A Perfect World
Phables - by Brad Guigar, same author that writes Greystone Inn, Evil Inc., Courting Disaster and Everything Cartooning. Brad has a gentle style and in this biweekly comic, he tells stories of living in Philidelphia.
Piled Higher and Deeper - Follows the adventures of students stuck in university earning their PhD (hence the title). Nice art and characterizations.
Player Versus Player
Pointless
Questionable Content - I recently reread the archives of this comic and remembered why I liked it so much. It's the characters and their interactions. Yes, there is funny, and sometimes, a lot of it, especially in the form of obscure music and literature references and indie-music snobbery, but the characters are what I care about in this comic. The short version: a young man makes friends with several females but cannot seem to hook up with any of them. Plenty of sexual tension (worthy of X-Files before that got lame) to keep the interests high. Some drama, some weirdness, and even anthro-PC. The author keeps coming up with fantastic T-shirt designs, as well. These shirts keep him afloat, as this is what he does, full time. Great stuff.
Sam and Fuzzy
Scary Go Round
Sev Cartoon Archives
Schlock Mercenary
The Seraph Inn
Sluggy Freelance
Soap on a Rope
Something Positive
Spamusement
Striptease comic
Stuff Sucks
Superosity
Surliness
Ugly Hill
Zap in Space
Zortic